#4983 THE UNEXPECTABLE BALANCE OF PROINFLAMMATORY CELLS IN PERITONEAL DIALYSIS PATIENTS

Abstract Background and Aims Chronic kidney disease (CKD) is a complex heterogeneous increasingly becoming global public health concern. It characterized by persistent inflammation state which appear to be caused cytokines, grown factors hormones. Peritoneal dialysis (PD) accounts for 9% of all replacement therapy (KRT) over time, some changes are expected occur in the peritoneal membrane mainly due exposure PD solutions, infectious processes non-infectious complications. This inflammatory process poorly understood needs further clarification, but Th17 cells Th1 seem involved. Therefore, we aimed quantify frequency peripheral immune concentration IL-17A blood (PB) effluent (PE) compare healthy control group. Method In cross-sectional study 26 patients 10 healthy, age sex-matched controls evaluated PB PE frequencies T lymphocytes, CD4, CD8 flow cytometry as well IL-17 concentrations using enzyme-linked immunosorbent assay. Comparisons were performed between different groups according modality, number exchanges, dialysate tonicity, extraneal use, infusion daily total volumes, type transport volume indexes. Statistical analyses SPSS statistics version 26. Results Table 1 summarizes main characteristics controls. Overall, comparison with group, was significantly lower (P = 0.001). On other hand, substantially expanded PE, compared also presented 0.061) those prescribed Extraneal had lowest 0.030). higher vs 0.012). Finally, lymphocytes high transporters high-average 0.021). Conclusion our cohort, proinflammatory cytokines. rather than increased, pointing predominant cytolytic activity increased. Treatment associated these cells, somehow counterbalancing millieu glucose concentrations.